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\left(-2^{3}\left(x^{2}\right)^{3}y^{3}\right)\times 2p^{2}q
Expand \left(2x^{2}y\right)^{3}.
\left(-2^{3}x^{6}y^{3}\right)\times 2p^{2}q
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
\left(-8x^{6}y^{3}\right)\times 2p^{2}q
Calculate 2 to the power of 3 and get 8.
-8x^{6}y^{3}\times 2p^{2}q
Multiply -1 and 8 to get -8.
-16x^{6}y^{3}p^{2}q
Multiply -8 and 2 to get -16.
\left(-2^{3}\left(x^{2}\right)^{3}y^{3}\right)\times 2p^{2}q
Expand \left(2x^{2}y\right)^{3}.
\left(-2^{3}x^{6}y^{3}\right)\times 2p^{2}q
To raise a power to another power, multiply the exponents. Multiply 2 and 3 to get 6.
\left(-8x^{6}y^{3}\right)\times 2p^{2}q
Calculate 2 to the power of 3 and get 8.
-8x^{6}y^{3}\times 2p^{2}q
Multiply -1 and 8 to get -8.
-16x^{6}y^{3}p^{2}q
Multiply -8 and 2 to get -16.