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3x\left(7y+4x\right)-\left(2y+8x\right)\left(2y+5x\right)
Combine 4x and -x to get 3x.
21xy+12x^{2}-\left(2y+8x\right)\left(2y+5x\right)
Use the distributive property to multiply 3x by 7y+4x.
21xy+12x^{2}-\left(4y^{2}+10yx+16xy+40x^{2}\right)
Apply the distributive property by multiplying each term of 2y+8x by each term of 2y+5x.
21xy+12x^{2}-\left(4y^{2}+26yx+40x^{2}\right)
Combine 10yx and 16xy to get 26yx.
21xy+12x^{2}-4y^{2}-26yx-40x^{2}
To find the opposite of 4y^{2}+26yx+40x^{2}, find the opposite of each term.
-5xy+12x^{2}-4y^{2}-40x^{2}
Combine 21xy and -26yx to get -5xy.
-5xy-28x^{2}-4y^{2}
Combine 12x^{2} and -40x^{2} to get -28x^{2}.
3x\left(7y+4x\right)-\left(2y+8x\right)\left(2y+5x\right)
Combine 4x and -x to get 3x.
21xy+12x^{2}-\left(2y+8x\right)\left(2y+5x\right)
Use the distributive property to multiply 3x by 7y+4x.
21xy+12x^{2}-\left(4y^{2}+10yx+16xy+40x^{2}\right)
Apply the distributive property by multiplying each term of 2y+8x by each term of 2y+5x.
21xy+12x^{2}-\left(4y^{2}+26yx+40x^{2}\right)
Combine 10yx and 16xy to get 26yx.
21xy+12x^{2}-4y^{2}-26yx-40x^{2}
To find the opposite of 4y^{2}+26yx+40x^{2}, find the opposite of each term.
-5xy+12x^{2}-4y^{2}-40x^{2}
Combine 21xy and -26yx to get -5xy.
-5xy-28x^{2}-4y^{2}
Combine 12x^{2} and -40x^{2} to get -28x^{2}.