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\left(3-16x\right)\left(x^{2}+8x+16\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+4\right)^{2}.
-125x^{2}-232x+48-16x^{3}
Use the distributive property to multiply 3-16x by x^{2}+8x+16 and combine like terms.
\left(3-16x\right)\left(x^{2}+8x+16\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(x+4\right)^{2}.
-125x^{2}-232x+48-16x^{3}
Use the distributive property to multiply 3-16x by x^{2}+8x+16 and combine like terms.