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x^{2}-xy-4x+yx-y^{2}-4y+4x-4y-16
Apply the distributive property by multiplying each term of x+y+4 by each term of x-y-4.
x^{2}-4x-y^{2}-4y+4x-4y-16
Combine -xy and yx to get 0.
x^{2}-y^{2}-4y-4y-16
Combine -4x and 4x to get 0.
x^{2}-y^{2}-8y-16
Combine -4y and -4y to get -8y.
x^{2}-xy-4x+yx-y^{2}-4y+4x-4y-16
Apply the distributive property by multiplying each term of x+y+4 by each term of x-y-4.
x^{2}-4x-y^{2}-4y+4x-4y-16
Combine -xy and yx to get 0.
x^{2}-y^{2}-4y-4y-16
Combine -4x and 4x to get 0.
x^{2}-y^{2}-8y-16
Combine -4y and -4y to get -8y.