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Differentiate w.r.t. x
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\left(\frac{64x^{3}a^{-3}}{27}\right)^{-\frac{2}{3}}
Express \frac{64x^{3}}{27}a^{-3} as a single fraction.
\frac{\left(64x^{3}a^{-3}\right)^{-\frac{2}{3}}}{27^{-\frac{2}{3}}}
To raise \frac{64x^{3}a^{-3}}{27} to a power, raise both numerator and denominator to the power and then divide.
\frac{64^{-\frac{2}{3}}\left(x^{3}\right)^{-\frac{2}{3}}\left(a^{-3}\right)^{-\frac{2}{3}}}{27^{-\frac{2}{3}}}
Expand \left(64x^{3}a^{-3}\right)^{-\frac{2}{3}}.
\frac{64^{-\frac{2}{3}}x^{-2}\left(a^{-3}\right)^{-\frac{2}{3}}}{27^{-\frac{2}{3}}}
To raise a power to another power, multiply the exponents. Multiply 3 and -\frac{2}{3} to get -2.
\frac{64^{-\frac{2}{3}}x^{-2}a^{2}}{27^{-\frac{2}{3}}}
To raise a power to another power, multiply the exponents. Multiply -3 and -\frac{2}{3} to get 2.
\frac{\frac{1}{16}x^{-2}a^{2}}{27^{-\frac{2}{3}}}
Calculate 64 to the power of -\frac{2}{3} and get \frac{1}{16}.
\frac{\frac{1}{16}x^{-2}a^{2}}{\frac{1}{9}}
Calculate 27 to the power of -\frac{2}{3} and get \frac{1}{9}.
\frac{1}{16}x^{-2}a^{2}\times 9
Divide \frac{1}{16}x^{-2}a^{2} by \frac{1}{9} by multiplying \frac{1}{16}x^{-2}a^{2} by the reciprocal of \frac{1}{9}.
\frac{9}{16}x^{-2}a^{2}
Multiply \frac{1}{16} and 9 to get \frac{9}{16}.