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Differentiate w.r.t. u
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64^{-\frac{3}{2}}u^{-\frac{3}{2}}
Expand \left(64u\right)^{-\frac{3}{2}}.
\frac{1}{512}u^{-\frac{3}{2}}
Calculate 64 to the power of -\frac{3}{2} and get \frac{1}{512}.
\frac{\mathrm{d}}{\mathrm{d}u}(64^{-\frac{3}{2}}u^{-\frac{3}{2}})
Expand \left(64u\right)^{-\frac{3}{2}}.
\frac{\mathrm{d}}{\mathrm{d}u}(\frac{1}{512}u^{-\frac{3}{2}})
Calculate 64 to the power of -\frac{3}{2} and get \frac{1}{512}.
-\frac{3}{2}\times \frac{1}{512}u^{-\frac{3}{2}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{3}{1024}u^{-\frac{3}{2}-1}
Multiply -\frac{3}{2} times \frac{1}{512} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.
-\frac{3}{1024}u^{-\frac{5}{2}}
Subtract 1 from -\frac{3}{2}.