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625p^{2}-750pq+225q^{2}-\left(15p-25q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(25p-15q\right)^{2}.
625p^{2}-750pq+225q^{2}-\left(225p^{2}-750pq+625q^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(15p-25q\right)^{2}.
625p^{2}-750pq+225q^{2}-225p^{2}+750pq-625q^{2}
To find the opposite of 225p^{2}-750pq+625q^{2}, find the opposite of each term.
400p^{2}-750pq+225q^{2}+750pq-625q^{2}
Combine 625p^{2} and -225p^{2} to get 400p^{2}.
400p^{2}+225q^{2}-625q^{2}
Combine -750pq and 750pq to get 0.
400p^{2}-400q^{2}
Combine 225q^{2} and -625q^{2} to get -400q^{2}.
625p^{2}-750pq+225q^{2}-\left(15p-25q\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(25p-15q\right)^{2}.
625p^{2}-750pq+225q^{2}-\left(225p^{2}-750pq+625q^{2}\right)
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(15p-25q\right)^{2}.
625p^{2}-750pq+225q^{2}-225p^{2}+750pq-625q^{2}
To find the opposite of 225p^{2}-750pq+625q^{2}, find the opposite of each term.
400p^{2}-750pq+225q^{2}+750pq-625q^{2}
Combine 625p^{2} and -225p^{2} to get 400p^{2}.
400p^{2}+225q^{2}-625q^{2}
Combine -750pq and 750pq to get 0.
400p^{2}-400q^{2}
Combine 225q^{2} and -625q^{2} to get -400q^{2}.