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16\left(15-18\right)^{4}
Calculate -2 to the power of 4 and get 16.
16\left(-3\right)^{4}
Subtract 18 from 15 to get -3.
16\times 81
Calculate -3 to the power of 4 and get 81.
1296
Multiply 16 and 81 to get 1296.