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\frac{-3\times 16}{4\times 9}
Multiply -\frac{3}{4} times \frac{16}{9} by multiplying numerator times numerator and denominator times denominator.
\frac{-48}{36}
Do the multiplications in the fraction \frac{-3\times 16}{4\times 9}.
-\frac{4}{3}
Reduce the fraction \frac{-48}{36} to lowest terms by extracting and canceling out 12.