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\frac{-\frac{1}{8}+16^{-1}}{6^{-2}}+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Calculate -2 to the power of -3 and get -\frac{1}{8}.
\frac{-\frac{1}{8}+\frac{1}{16}}{6^{-2}}+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Calculate 16 to the power of -1 and get \frac{1}{16}.
\frac{-\frac{1}{16}}{6^{-2}}+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Add -\frac{1}{8} and \frac{1}{16} to get -\frac{1}{16}.
\frac{-\frac{1}{16}}{\frac{1}{36}}+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Calculate 6 to the power of -2 and get \frac{1}{36}.
-\frac{1}{16}\times 36+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Divide -\frac{1}{16} by \frac{1}{36} by multiplying -\frac{1}{16} by the reciprocal of \frac{1}{36}.
-\frac{9}{4}+2^{3}\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Multiply -\frac{1}{16} and 36 to get -\frac{9}{4}.
-\frac{9}{4}+8\times \frac{-1^{-8}-2^{-2}}{2^{3}-2^{4}}
Calculate 2 to the power of 3 and get 8.
-\frac{9}{4}+8\times \frac{-1-2^{-2}}{2^{3}-2^{4}}
Calculate 1 to the power of -8 and get 1.
-\frac{9}{4}+8\times \frac{-1-\frac{1}{4}}{2^{3}-2^{4}}
Calculate 2 to the power of -2 and get \frac{1}{4}.
-\frac{9}{4}+8\times \frac{-\frac{5}{4}}{2^{3}-2^{4}}
Subtract \frac{1}{4} from -1 to get -\frac{5}{4}.
-\frac{9}{4}+8\times \frac{-\frac{5}{4}}{8-2^{4}}
Calculate 2 to the power of 3 and get 8.
-\frac{9}{4}+8\times \frac{-\frac{5}{4}}{8-16}
Calculate 2 to the power of 4 and get 16.
-\frac{9}{4}+8\times \frac{-\frac{5}{4}}{-8}
Subtract 16 from 8 to get -8.
-\frac{9}{4}+8\times \frac{-5}{4\left(-8\right)}
Express \frac{-\frac{5}{4}}{-8} as a single fraction.
-\frac{9}{4}+8\times \frac{-5}{-32}
Multiply 4 and -8 to get -32.
-\frac{9}{4}+8\times \frac{5}{32}
Fraction \frac{-5}{-32} can be simplified to \frac{5}{32} by removing the negative sign from both the numerator and the denominator.
-\frac{9}{4}+\frac{5}{4}
Multiply 8 and \frac{5}{32} to get \frac{5}{4}.
-1
Add -\frac{9}{4} and \frac{5}{4} to get -1.