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Differentiate w.r.t. x
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\frac{-\frac{2}{3}xyz^{3}}{-\frac{3}{5}x^{5}y^{4}z^{6}}
Fraction \frac{-2}{3} can be rewritten as -\frac{2}{3} by extracting the negative sign.
\frac{-\frac{2}{3}}{-\frac{3}{5}y^{3}z^{3}x^{4}}
Cancel out xyz^{3} in both numerator and denominator.
\frac{-2}{3\left(-\frac{3}{5}\right)y^{3}z^{3}x^{4}}
Express \frac{-\frac{2}{3}}{-\frac{3}{5}y^{3}z^{3}x^{4}} as a single fraction.
\frac{-2}{-\frac{9}{5}y^{3}z^{3}x^{4}}
Multiply 3 and -\frac{3}{5} to get -\frac{9}{5}.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{\frac{2yz^{3}}{3}}{-\frac{3y^{4}z^{6}}{5}}\right)x^{1-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{10}{9\left(yz\right)^{3}}x^{-4})
Do the arithmetic.
-4\times \frac{10}{9\left(yz\right)^{3}}x^{-4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{40}{9\left(yz\right)^{3}}\right)x^{-5}
Do the arithmetic.