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Differentiate w.r.t. x
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8^{-\frac{2}{3}}x^{-\frac{2}{3}}
Expand \left(8x\right)^{-\frac{2}{3}}.
\frac{1}{4}x^{-\frac{2}{3}}
Calculate 8 to the power of -\frac{2}{3} and get \frac{1}{4}.
\frac{\mathrm{d}}{\mathrm{d}x}(8^{-\frac{2}{3}}x^{-\frac{2}{3}})
Expand \left(8x\right)^{-\frac{2}{3}}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{4}x^{-\frac{2}{3}})
Calculate 8 to the power of -\frac{2}{3} and get \frac{1}{4}.
-\frac{2}{3}\times \frac{1}{4}x^{-\frac{2}{3}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{1}{6}x^{-\frac{2}{3}-1}
Multiply -\frac{2}{3} times \frac{1}{4} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.
-\frac{1}{6}x^{-\frac{5}{3}}
Subtract 1 from -\frac{2}{3}.