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16\left(x^{2}-4x+4\right)-25\left(y+1\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-2\right)^{2}.
16x^{2}-64x+64-25\left(y+1\right)^{2}
Use the distributive property to multiply 16 by x^{2}-4x+4.
16x^{2}-64x+64-25\left(y^{2}+2y+1\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+1\right)^{2}.
16x^{2}-64x+64-25y^{2}-50y-25
Use the distributive property to multiply -25 by y^{2}+2y+1.
16x^{2}-64x+39-25y^{2}-50y
Subtract 25 from 64 to get 39.
16\left(x^{2}-4x+4\right)-25\left(y+1\right)^{2}
Use binomial theorem \left(a-b\right)^{2}=a^{2}-2ab+b^{2} to expand \left(x-2\right)^{2}.
16x^{2}-64x+64-25\left(y+1\right)^{2}
Use the distributive property to multiply 16 by x^{2}-4x+4.
16x^{2}-64x+64-25\left(y^{2}+2y+1\right)
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(y+1\right)^{2}.
16x^{2}-64x+64-25y^{2}-50y-25
Use the distributive property to multiply -25 by y^{2}+2y+1.
16x^{2}-64x+39-25y^{2}-50y
Subtract 25 from 64 to get 39.