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16\left(x^{2}\right)^{2}+8x^{2}+1-\left(4x\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(4x^{2}+1\right)^{2}.
16x^{4}+8x^{2}+1-\left(4x\right)^{2}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
16x^{4}+8x^{2}+1-4^{2}x^{2}
Expand \left(4x\right)^{2}.
16x^{4}+8x^{2}+1-16x^{2}
Calculate 4 to the power of 2 and get 16.
16x^{4}-8x^{2}+1
Combine 8x^{2} and -16x^{2} to get -8x^{2}.
16\left(x^{2}\right)^{2}+8x^{2}+1-\left(4x\right)^{2}
Use binomial theorem \left(a+b\right)^{2}=a^{2}+2ab+b^{2} to expand \left(4x^{2}+1\right)^{2}.
16x^{4}+8x^{2}+1-\left(4x\right)^{2}
To raise a power to another power, multiply the exponents. Multiply 2 and 2 to get 4.
16x^{4}+8x^{2}+1-4^{2}x^{2}
Expand \left(4x\right)^{2}.
16x^{4}+8x^{2}+1-16x^{2}
Calculate 4 to the power of 2 and get 16.
16x^{4}-8x^{2}+1
Combine 8x^{2} and -16x^{2} to get -8x^{2}.