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Differentiate w.r.t. x
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4\times 25x^{4-1}+3\left(-12\right)x^{3-1}+2yx^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
100x^{4-1}+3\left(-12\right)x^{3-1}+2yx^{2-1}
Multiply 4 times 25.
100x^{3}+3\left(-12\right)x^{3-1}+2yx^{2-1}
Subtract 1 from 4.
100x^{3}-36x^{3-1}+2yx^{2-1}
Multiply 3 times -12.
100x^{3}-36x^{2}+2yx^{2-1}
Subtract 1 from 3.
100x^{3}-36x^{2}+2yx^{1}
Subtract 1 from 2.
100x^{3}-36x^{2}+2yx
For any term t, t^{1}=t.