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Differentiate w.r.t. x
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\frac{81x^{8}y^{0}z^{-4}z^{-4}}{81x^{12}y^{-12}z^{-4}}
To multiply powers of the same base, add their exponents. Add 4 and 4 to get 8.
\frac{81x^{8}y^{0}z^{-8}}{81x^{12}y^{-12}z^{-4}}
To multiply powers of the same base, add their exponents. Add -4 and -4 to get -8.
\frac{z^{-8}y^{0}}{y^{-12}z^{-4}x^{4}}
Cancel out 81x^{8} in both numerator and denominator.
\frac{z^{-8}y^{12}}{z^{-4}x^{4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{y^{12}}{x^{4}z^{4}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{81y^{0}x^{4}}{z^{4}z^{4}\times \frac{81}{z^{4}y^{12}}}x^{4-12})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{x^{4}y^{12}}{z^{4}}x^{-8})
Do the arithmetic.
-8\times \frac{x^{4}y^{12}}{z^{4}}x^{-8-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{8x^{4}y^{12}}{z^{4}}\right)x^{-9}
Do the arithmetic.