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\frac{4\left(-4x+1\right)}{\left(4x-1\right)\left(x+2\right)}
Factor the expressions that are not already factored.
\frac{-4\left(4x-1\right)}{\left(4x-1\right)\left(x+2\right)}
Extract the negative sign in 1-4x.
\frac{-4}{x+2}
Cancel out 4x-1 in both numerator and denominator.
\frac{4\left(-4x+1\right)}{\left(4x-1\right)\left(x+2\right)}
Factor the expressions that are not already factored.
\frac{-4\left(4x-1\right)}{\left(4x-1\right)\left(x+2\right)}
Extract the negative sign in 1-4x.
\frac{-4}{x+2}
Cancel out 4x-1 in both numerator and denominator.