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\frac{\left(x^{2}-16\right)\left(x^{2}-2x-8\right)}{\left(x^{2}+5x+6\right)\left(x^{2}+5x+4\right)}
Divide \frac{x^{2}-16}{x^{2}+5x+6} by \frac{x^{2}+5x+4}{x^{2}-2x-8} by multiplying \frac{x^{2}-16}{x^{2}+5x+6} by the reciprocal of \frac{x^{2}+5x+4}{x^{2}-2x-8}.
\frac{\left(x+2\right)\left(x+4\right)\left(x-4\right)^{2}}{\left(x+1\right)\left(x+2\right)\left(x+3\right)\left(x+4\right)}
Factor the expressions that are not already factored.
\frac{\left(x-4\right)^{2}}{\left(x+1\right)\left(x+3\right)}
Cancel out \left(x+2\right)\left(x+4\right) in both numerator and denominator.
\frac{x^{2}-8x+16}{x^{2}+4x+3}
Expand the expression.
\frac{\left(x^{2}-16\right)\left(x^{2}-2x-8\right)}{\left(x^{2}+5x+6\right)\left(x^{2}+5x+4\right)}
Divide \frac{x^{2}-16}{x^{2}+5x+6} by \frac{x^{2}+5x+4}{x^{2}-2x-8} by multiplying \frac{x^{2}-16}{x^{2}+5x+6} by the reciprocal of \frac{x^{2}+5x+4}{x^{2}-2x-8}.
\frac{\left(x+2\right)\left(x+4\right)\left(x-4\right)^{2}}{\left(x+1\right)\left(x+2\right)\left(x+3\right)\left(x+4\right)}
Factor the expressions that are not already factored.
\frac{\left(x-4\right)^{2}}{\left(x+1\right)\left(x+3\right)}
Cancel out \left(x+2\right)\left(x+4\right) in both numerator and denominator.
\frac{x^{2}-8x+16}{x^{2}+4x+3}
Expand the expression.