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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{\sqrt{x}\sqrt[3]{x}}{x^{-\frac{1}{4}}})
Fraction \frac{-1}{4} can be rewritten as -\frac{1}{4} by extracting the negative sign.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{\sqrt[3]{x}\sqrt{x}}{x^{-\frac{1}{4}}})
Factor the expressions that are not already factored in \frac{\sqrt{x}\sqrt[3]{x}}{x^{-\frac{1}{4}}}.
\frac{\mathrm{d}}{\mathrm{d}x}(\sqrt{x}x^{\frac{7}{12}})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{\frac{13}{12}})
Expand the expression.
\frac{13}{12}x^{\frac{13}{12}-1}
The derivative of ax^{n} is nax^{n-1}.
\frac{13}{12}\sqrt[12]{x}
Subtract 1 from \frac{13}{12}.