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Differentiate w.r.t. q
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\frac{-21p^{9}q^{4}\times 12pq^{4}}{16pq^{4}\times 7p^{2}q^{8}}
Divide \frac{-21p^{9}q^{4}}{16pq^{4}} by \frac{7p^{2}q^{8}}{12pq^{4}} by multiplying \frac{-21p^{9}q^{4}}{16pq^{4}} by the reciprocal of \frac{7p^{2}q^{8}}{12pq^{4}}.
\frac{-3\times 3pp^{6}}{4q^{4}}
Cancel out 4\times 7pp^{2}q^{4}q^{4} in both numerator and denominator.
\frac{-3\times 3p^{7}}{4q^{4}}
To multiply powers of the same base, add their exponents. Add 1 and 6 to get 7.
\frac{-9p^{7}}{4q^{4}}
Multiply -3 and 3 to get -9.