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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{z^{2}y^{9}}{zy^{9}}x^{20-5})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(zx^{15})
Do the arithmetic.
15zx^{15-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
15zx^{14}
Do the arithmetic.
zx^{15}
Cancel out zx^{5}y^{9} in both numerator and denominator.