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\frac{\left(x^{2}-64\right)\left(x^{2}+3x-40\right)}{\left(8x-40\right)\left(x^{2}+16x+64\right)}
Divide \frac{x^{2}-64}{8x-40} by \frac{x^{2}+16x+64}{x^{2}+3x-40} by multiplying \frac{x^{2}-64}{8x-40} by the reciprocal of \frac{x^{2}+16x+64}{x^{2}+3x-40}.
\frac{\left(x-8\right)\left(x-5\right)\left(x+8\right)^{2}}{8\left(x-5\right)\left(x+8\right)^{2}}
Factor the expressions that are not already factored.
\frac{x-8}{8}
Cancel out \left(x-5\right)\left(x+8\right)^{2} in both numerator and denominator.
\frac{\left(x^{2}-64\right)\left(x^{2}+3x-40\right)}{\left(8x-40\right)\left(x^{2}+16x+64\right)}
Divide \frac{x^{2}-64}{8x-40} by \frac{x^{2}+16x+64}{x^{2}+3x-40} by multiplying \frac{x^{2}-64}{8x-40} by the reciprocal of \frac{x^{2}+16x+64}{x^{2}+3x-40}.
\frac{\left(x-8\right)\left(x-5\right)\left(x+8\right)^{2}}{8\left(x-5\right)\left(x+8\right)^{2}}
Factor the expressions that are not already factored.
\frac{x-8}{8}
Cancel out \left(x-5\right)\left(x+8\right)^{2} in both numerator and denominator.