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\frac{\left(x^{2}-10x+16\right)\left(x^{2}+6x-40\right)}{\left(x^{2}-9x+20\right)\left(4-x^{2}\right)}
Divide \frac{x^{2}-10x+16}{x^{2}-9x+20} by \frac{4-x^{2}}{x^{2}+6x-40} by multiplying \frac{x^{2}-10x+16}{x^{2}-9x+20} by the reciprocal of \frac{4-x^{2}}{x^{2}+6x-40}.
\frac{\left(x-8\right)\left(x-4\right)\left(x-2\right)\left(x+10\right)}{\left(x-5\right)\left(x-4\right)\left(x-2\right)\left(-x-2\right)}
Factor the expressions that are not already factored.
\frac{\left(x-8\right)\left(x+10\right)}{\left(x-5\right)\left(-x-2\right)}
Cancel out \left(x-4\right)\left(x-2\right) in both numerator and denominator.
\frac{x^{2}+2x-80}{-x^{2}+3x+10}
Expand the expression.
\frac{\left(x^{2}-10x+16\right)\left(x^{2}+6x-40\right)}{\left(x^{2}-9x+20\right)\left(4-x^{2}\right)}
Divide \frac{x^{2}-10x+16}{x^{2}-9x+20} by \frac{4-x^{2}}{x^{2}+6x-40} by multiplying \frac{x^{2}-10x+16}{x^{2}-9x+20} by the reciprocal of \frac{4-x^{2}}{x^{2}+6x-40}.
\frac{\left(x-8\right)\left(x-4\right)\left(x-2\right)\left(x+10\right)}{\left(x-5\right)\left(x-4\right)\left(x-2\right)\left(-x-2\right)}
Factor the expressions that are not already factored.
\frac{\left(x-8\right)\left(x+10\right)}{\left(x-5\right)\left(-x-2\right)}
Cancel out \left(x-4\right)\left(x-2\right) in both numerator and denominator.
\frac{x^{2}+2x-80}{-x^{2}+3x+10}
Expand the expression.