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\frac{\left(x^{2}+x-20\right)\left(x^{2}-25\right)}{\left(x^{2}-10x+25\right)\left(x^{2}-16\right)}
Divide \frac{x^{2}+x-20}{x^{2}-10x+25} by \frac{x^{2}-16}{x^{2}-25} by multiplying \frac{x^{2}+x-20}{x^{2}-10x+25} by the reciprocal of \frac{x^{2}-16}{x^{2}-25}.
\frac{\left(x-5\right)\left(x-4\right)\left(x+5\right)^{2}}{\left(x-4\right)\left(x+4\right)\left(x-5\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(x+5\right)^{2}}{\left(x-5\right)\left(x+4\right)}
Cancel out \left(x-5\right)\left(x-4\right) in both numerator and denominator.
\frac{x^{2}+10x+25}{x^{2}-x-20}
Expand the expression.
\frac{\left(x^{2}+x-20\right)\left(x^{2}-25\right)}{\left(x^{2}-10x+25\right)\left(x^{2}-16\right)}
Divide \frac{x^{2}+x-20}{x^{2}-10x+25} by \frac{x^{2}-16}{x^{2}-25} by multiplying \frac{x^{2}+x-20}{x^{2}-10x+25} by the reciprocal of \frac{x^{2}-16}{x^{2}-25}.
\frac{\left(x-5\right)\left(x-4\right)\left(x+5\right)^{2}}{\left(x-4\right)\left(x+4\right)\left(x-5\right)^{2}}
Factor the expressions that are not already factored.
\frac{\left(x+5\right)^{2}}{\left(x-5\right)\left(x+4\right)}
Cancel out \left(x-5\right)\left(x-4\right) in both numerator and denominator.
\frac{x^{2}+10x+25}{x^{2}-x-20}
Expand the expression.