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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{1}x^{-9-9})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(x^{-18})
Do the arithmetic.
-18x^{-18-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-18x^{-19}
Do the arithmetic.
\frac{1}{x^{18}}
Rewrite x^{9} as x^{-9}x^{18}. Cancel out x^{-9} in both numerator and denominator.