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x+4>0 x+1<0
For the quotient to be negative, x+4 and x+1 have to be of the opposite signs. Consider the case when x+4 is positive and x+1 is negative.
x\in \left(-4,-1\right)
The solution satisfying both inequalities is x\in \left(-4,-1\right).
x+1>0 x+4<0
Consider the case when x+1 is positive and x+4 is negative.
x\in \emptyset
This is false for any x.
x\in \left(-4,-1\right)
The final solution is the union of the obtained solutions.