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Differentiate w.r.t. x
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\frac{x^{3}\frac{\mathrm{d}}{\mathrm{d}x}(4x^{5}-3x^{2})-\left(4x^{5}-3x^{2}\right)\frac{\mathrm{d}}{\mathrm{d}x}(x^{3})}{\left(x^{3}\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{x^{3}\left(5\times 4x^{5-1}+2\left(-3\right)x^{2-1}\right)-\left(4x^{5}-3x^{2}\right)\times 3x^{3-1}}{\left(x^{3}\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{x^{3}\left(20x^{4}-6x^{1}\right)-\left(4x^{5}-3x^{2}\right)\times 3x^{2}}{\left(x^{3}\right)^{2}}
Simplify.
\frac{x^{3}\times 20x^{4}+x^{3}\left(-6\right)x^{1}-\left(4x^{5}-3x^{2}\right)\times 3x^{2}}{\left(x^{3}\right)^{2}}
Multiply x^{3} times 20x^{4}-6x^{1}.
\frac{x^{3}\times 20x^{4}+x^{3}\left(-6\right)x^{1}-\left(4x^{5}\times 3x^{2}-3x^{2}\times 3x^{2}\right)}{\left(x^{3}\right)^{2}}
Multiply 4x^{5}-3x^{2} times 3x^{2}.
\frac{20x^{3+4}-6x^{3+1}-\left(4\times 3x^{5+2}-3\times 3x^{2+2}\right)}{\left(x^{3}\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{20x^{7}-6x^{4}-\left(12x^{7}-9x^{4}\right)}{\left(x^{3}\right)^{2}}
Simplify.
\frac{8x^{7}+3x^{4}}{\left(x^{3}\right)^{2}}
Combine like terms.