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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{b^{2}c^{4}}{1}a^{1-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(b^{2}c^{4}\times \frac{1}{a})
Do the arithmetic.
-b^{2}c^{4}a^{-1-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-b^{2}c^{4}\right)a^{-2}
Do the arithmetic.
\frac{b^{2}c^{4}}{a}
Cancel out a in both numerator and denominator.