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Differentiate w.r.t. a
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\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{1}a^{2-\left(-4\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(a^{6})
Do the arithmetic.
6a^{6-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
6a^{5}
Do the arithmetic.
a^{6}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent. Subtract -4 from 2 to get 6.