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\frac{2\times 8\times 8^{3}}{2^{-5}}
Cancel out 8 in both numerator and denominator.
8\times 2^{6}\times 8^{3}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
8^{4}\times 2^{6}
To multiply powers of the same base, add their exponents. Add 1 and 3 to get 4.
4096\times 2^{6}
Calculate 8 to the power of 4 and get 4096.
4096\times 64
Calculate 2 to the power of 6 and get 64.
262144
Multiply 4096 and 64 to get 262144.