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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{60z^{2}y^{4}}{4z^{2}y^{3}}x^{6-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(15yx^{4})
Do the arithmetic.
4\times 15yx^{4-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
60yx^{3}
Do the arithmetic.
15yx^{4}
Cancel out 4x^{2}z^{2}y^{3} in both numerator and denominator.