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Differentiate w.r.t. x
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\frac{4}{\left(x-2\right)\left(x+4\right)}-\frac{5}{\left(x-2\right)\left(x+5\right)}
Factor x^{2}+2x-8. Factor x^{2}+3x-10.
\frac{4\left(x+5\right)}{\left(x-2\right)\left(x+4\right)\left(x+5\right)}-\frac{5\left(x+4\right)}{\left(x-2\right)\left(x+4\right)\left(x+5\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of \left(x-2\right)\left(x+4\right) and \left(x-2\right)\left(x+5\right) is \left(x-2\right)\left(x+4\right)\left(x+5\right). Multiply \frac{4}{\left(x-2\right)\left(x+4\right)} times \frac{x+5}{x+5}. Multiply \frac{5}{\left(x-2\right)\left(x+5\right)} times \frac{x+4}{x+4}.
\frac{4\left(x+5\right)-5\left(x+4\right)}{\left(x-2\right)\left(x+4\right)\left(x+5\right)}
Since \frac{4\left(x+5\right)}{\left(x-2\right)\left(x+4\right)\left(x+5\right)} and \frac{5\left(x+4\right)}{\left(x-2\right)\left(x+4\right)\left(x+5\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4x+20-5x-20}{\left(x-2\right)\left(x+4\right)\left(x+5\right)}
Do the multiplications in 4\left(x+5\right)-5\left(x+4\right).
\frac{-x}{\left(x-2\right)\left(x+4\right)\left(x+5\right)}
Combine like terms in 4x+20-5x-20.
\frac{-x}{x^{3}+7x^{2}+2x-40}
Expand \left(x-2\right)\left(x+4\right)\left(x+5\right).