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Differentiate w.r.t. a
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\frac{4^{-3}b^{-2}\times \frac{1}{c}a^{2}}{2^{2}b^{3}c^{4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{4^{-3}a^{2}}{2^{2}b^{5}c^{5}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{\frac{1}{64}a^{2}}{2^{2}b^{5}c^{5}}
Calculate 4 to the power of -3 and get \frac{1}{64}.
\frac{\frac{1}{64}a^{2}}{4b^{5}c^{5}}
Calculate 2 to the power of 2 and get 4.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{64cb^{2}\times 4b^{3}c^{4}}a^{1-\left(-1\right)})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{256\left(bc\right)^{5}}a^{2})
Do the arithmetic.
2\times \frac{1}{256\left(bc\right)^{5}}a^{2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{1}{128\left(bc\right)^{5}}a^{1}
Do the arithmetic.
\frac{1}{128\left(bc\right)^{5}}a
For any term t, t^{1}=t.