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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{30y^{8}z^{9}}{5ay^{2}z^{9}}x^{4-6})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{6y^{6}}{a}x^{-2})
Do the arithmetic.
-2\times \frac{6y^{6}}{a}x^{-2-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{12y^{6}}{a}\right)x^{-3}
Do the arithmetic.
\frac{6y^{6}}{ax^{2}}
Cancel out 5y^{2}x^{4}z^{9} in both numerator and denominator.