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Differentiate w.r.t. x
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\frac{3}{2x+1}+\frac{8}{\left(x-4\right)\left(2x+1\right)}
Factor 2x^{2}-7x-4.
\frac{3\left(x-4\right)}{\left(x-4\right)\left(2x+1\right)}+\frac{8}{\left(x-4\right)\left(2x+1\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 2x+1 and \left(x-4\right)\left(2x+1\right) is \left(x-4\right)\left(2x+1\right). Multiply \frac{3}{2x+1} times \frac{x-4}{x-4}.
\frac{3\left(x-4\right)+8}{\left(x-4\right)\left(2x+1\right)}
Since \frac{3\left(x-4\right)}{\left(x-4\right)\left(2x+1\right)} and \frac{8}{\left(x-4\right)\left(2x+1\right)} have the same denominator, add them by adding their numerators.
\frac{3x-12+8}{\left(x-4\right)\left(2x+1\right)}
Do the multiplications in 3\left(x-4\right)+8.
\frac{3x-4}{\left(x-4\right)\left(2x+1\right)}
Combine like terms in 3x-12+8.
\frac{3x-4}{2x^{2}-7x-4}
Expand \left(x-4\right)\left(2x+1\right).
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3}{2x+1}+\frac{8}{\left(x-4\right)\left(2x+1\right)})
Factor 2x^{2}-7x-4.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3\left(x-4\right)}{\left(x-4\right)\left(2x+1\right)}+\frac{8}{\left(x-4\right)\left(2x+1\right)})
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 2x+1 and \left(x-4\right)\left(2x+1\right) is \left(x-4\right)\left(2x+1\right). Multiply \frac{3}{2x+1} times \frac{x-4}{x-4}.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3\left(x-4\right)+8}{\left(x-4\right)\left(2x+1\right)})
Since \frac{3\left(x-4\right)}{\left(x-4\right)\left(2x+1\right)} and \frac{8}{\left(x-4\right)\left(2x+1\right)} have the same denominator, add them by adding their numerators.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3x-12+8}{\left(x-4\right)\left(2x+1\right)})
Do the multiplications in 3\left(x-4\right)+8.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3x-4}{\left(x-4\right)\left(2x+1\right)})
Combine like terms in 3x-12+8.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3x-4}{2x^{2}-7x-4})
Use the distributive property to multiply x-4 by 2x+1 and combine like terms.
\frac{\left(2x^{2}-7x^{1}-4\right)\frac{\mathrm{d}}{\mathrm{d}x}(3x^{1}-4)-\left(3x^{1}-4\right)\frac{\mathrm{d}}{\mathrm{d}x}(2x^{2}-7x^{1}-4)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
For any two differentiable functions, the derivative of the quotient of two functions is the denominator times the derivative of the numerator minus the numerator times the derivative of the denominator, all divided by the denominator squared.
\frac{\left(2x^{2}-7x^{1}-4\right)\times 3x^{1-1}-\left(3x^{1}-4\right)\left(2\times 2x^{2-1}-7x^{1-1}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{\left(2x^{2}-7x^{1}-4\right)\times 3x^{0}-\left(3x^{1}-4\right)\left(4x^{1}-7x^{0}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
Simplify.
\frac{2x^{2}\times 3x^{0}-7x^{1}\times 3x^{0}-4\times 3x^{0}-\left(3x^{1}-4\right)\left(4x^{1}-7x^{0}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
Multiply 2x^{2}-7x^{1}-4 times 3x^{0}.
\frac{2x^{2}\times 3x^{0}-7x^{1}\times 3x^{0}-4\times 3x^{0}-\left(3x^{1}\times 4x^{1}+3x^{1}\left(-7\right)x^{0}-4\times 4x^{1}-4\left(-7\right)x^{0}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
Multiply 3x^{1}-4 times 4x^{1}-7x^{0}.
\frac{2\times 3x^{2}-7\times 3x^{1}-4\times 3x^{0}-\left(3\times 4x^{1+1}+3\left(-7\right)x^{1}-4\times 4x^{1}-4\left(-7\right)x^{0}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
To multiply powers of the same base, add their exponents.
\frac{6x^{2}-21x^{1}-12x^{0}-\left(12x^{2}-21x^{1}-16x^{1}+28x^{0}\right)}{\left(2x^{2}-7x^{1}-4\right)^{2}}
Simplify.
\frac{-6x^{2}+16x^{1}-40x^{0}}{\left(2x^{2}-7x^{1}-4\right)^{2}}
Combine like terms.
\frac{-6x^{2}+16x-40x^{0}}{\left(2x^{2}-7x-4\right)^{2}}
For any term t, t^{1}=t.
\frac{-6x^{2}+16x-40}{\left(2x^{2}-7x-4\right)^{2}}
For any term t except 0, t^{0}=1.