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Differentiate w.r.t. a
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\frac{25^{-2}a^{-4}}{10\times 5^{3}a^{-8}}
Cancel out X in both numerator and denominator.
\frac{25^{-2}a^{4}}{10\times 5^{3}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\frac{1}{625}a^{4}}{10\times 5^{3}}
Calculate 25 to the power of -2 and get \frac{1}{625}.
\frac{\frac{1}{625}a^{4}}{10\times 125}
Calculate 5 to the power of 3 and get 125.
\frac{\frac{1}{625}a^{4}}{1250}
Multiply 10 and 125 to get 1250.
\frac{1}{781250}a^{4}
Divide \frac{1}{625}a^{4} by 1250 to get \frac{1}{781250}a^{4}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{25^{-2}a^{-4}}{10\times 5^{3}a^{-8}})
Cancel out X in both numerator and denominator.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{25^{-2}a^{4}}{10\times 5^{3}})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{\frac{1}{625}a^{4}}{10\times 5^{3}})
Calculate 25 to the power of -2 and get \frac{1}{625}.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{\frac{1}{625}a^{4}}{10\times 125})
Calculate 5 to the power of 3 and get 125.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{\frac{1}{625}a^{4}}{1250})
Multiply 10 and 125 to get 1250.
\frac{\mathrm{d}}{\mathrm{d}a}(\frac{1}{781250}a^{4})
Divide \frac{1}{625}a^{4} by 1250 to get \frac{1}{781250}a^{4}.
4\times \frac{1}{781250}a^{4-1}
The derivative of ax^{n} is nax^{n-1}.
\frac{2}{390625}a^{4-1}
Multiply 4 times \frac{1}{781250}.
\frac{2}{390625}a^{3}
Subtract 1 from 4.