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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{18y^{2}z^{5}}{6yz^{2}}x^{6-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(3yz^{3}x^{3})
Do the arithmetic.
3\times 3yz^{3}x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
9yz^{3}x^{2}
Do the arithmetic.
3yx^{3}z^{3}
Cancel out 6yz^{2}x^{3} in both numerator and denominator.