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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\frac{15z^{3}y^{4}}{20y^{4}z^{6}}x^{6-3})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{3}{4z^{3}}x^{3})
Do the arithmetic.
3\times \frac{3}{4z^{3}}x^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\frac{9}{4z^{3}}x^{2}
Do the arithmetic.
\frac{3x^{3}}{4z^{3}}
Cancel out 5x^{3}z^{3}y^{4} in both numerator and denominator.