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\frac{3628800}{\left(10-2\right)!\times 2!}
The factorial of 10 is 3628800.
\frac{3628800}{8!\times 2!}
Subtract 2 from 10 to get 8.
\frac{3628800}{40320\times 2!}
The factorial of 8 is 40320.
\frac{3628800}{40320\times 2}
The factorial of 2 is 2.
\frac{3628800}{80640}
Multiply 40320 and 2 to get 80640.
45
Divide 3628800 by 80640 to get 45.