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Differentiate w.r.t. q
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\frac{4p-q}{\left(4p+q\right)\left(4p-q\right)}-\frac{4p+q}{\left(4p+q\right)\left(4p-q\right)}
To add or subtract expressions, expand them to make their denominators the same. Least common multiple of 4p+q and 4p-q is \left(4p+q\right)\left(4p-q\right). Multiply \frac{1}{4p+q} times \frac{4p-q}{4p-q}. Multiply \frac{1}{4p-q} times \frac{4p+q}{4p+q}.
\frac{4p-q-\left(4p+q\right)}{\left(4p+q\right)\left(4p-q\right)}
Since \frac{4p-q}{\left(4p+q\right)\left(4p-q\right)} and \frac{4p+q}{\left(4p+q\right)\left(4p-q\right)} have the same denominator, subtract them by subtracting their numerators.
\frac{4p-q-4p-q}{\left(4p+q\right)\left(4p-q\right)}
Do the multiplications in 4p-q-\left(4p+q\right).
\frac{-2q}{\left(4p+q\right)\left(4p-q\right)}
Combine like terms in 4p-q-4p-q.
\frac{-2q}{16p^{2}-q^{2}}
Expand \left(4p+q\right)\left(4p-q\right).