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Differentiate w.r.t. x
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-\frac{3}{4}\times \frac{1}{4}x^{-\frac{3}{4}-1}
The derivative of ax^{n} is nax^{n-1}.
-\frac{3}{16}x^{-\frac{3}{4}-1}
Multiply -\frac{3}{4} times \frac{1}{4} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.
-\frac{3}{16}x^{-\frac{7}{4}}
Subtract 1 from -\frac{3}{4}.