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\frac{4}{16\left(-1\right)}
Divide \frac{1}{16} by \frac{-1}{4} by multiplying \frac{1}{16} by the reciprocal of \frac{-1}{4}.
\frac{4}{-16}
Multiply 16 and -1 to get -16.
-\frac{1}{4}
Reduce the fraction \frac{4}{-16} to lowest terms by extracting and canceling out 4.