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Differentiate w.r.t. a
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\left(\frac{1}{16}\right)^{1}a^{1}s^{1}\left(-\frac{1}{4}\right)^{1}a^{1}s^{1}
Use the rules of exponents to simplify the expression.
\left(\frac{1}{16}\right)^{1}\left(-\frac{1}{4}\right)^{1}a^{1}a^{1}s^{1}s^{1}
Use the Commutative Property of Multiplication.
\left(\frac{1}{16}\right)^{1}\left(-\frac{1}{4}\right)^{1}a^{1+1}s^{1+1}
To multiply powers of the same base, add their exponents.
\left(\frac{1}{16}\right)^{1}\left(-\frac{1}{4}\right)^{1}a^{2}s^{1+1}
Add the exponents 1 and 1.
\left(\frac{1}{16}\right)^{1}\left(-\frac{1}{4}\right)^{1}a^{2}s^{2}
Add the exponents 1 and 1.
-\frac{1}{64}a^{2}s^{2}
Multiply \frac{1}{16} times -\frac{1}{4} by multiplying numerator times numerator and denominator times denominator. Then reduce the fraction to lowest terms if possible.