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Differentiate w.r.t. x
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\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{5z^{6}y^{14}}{60z^{2}y^{3}}\right)x^{11-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}x}(\left(-\frac{z^{4}y^{11}}{12}\right)x^{9})
Do the arithmetic.
9\left(-\frac{z^{4}y^{11}}{12}\right)x^{9-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{3z^{4}y^{11}}{4}\right)x^{8}
Do the arithmetic.
\frac{-z^{4}x^{9}y^{11}}{12}
Cancel out 5x^{2}z^{2}y^{3} in both numerator and denominator.