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Differentiate w.r.t. m
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\frac{\left(-4\right)^{1}m^{5}n^{2}}{6^{1}m^{2}n^{6}}
Use the rules of exponents to simplify the expression.
\frac{\left(-4\right)^{1}}{6^{1}}m^{5-2}n^{2-6}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\left(-4\right)^{1}}{6^{1}}m^{3}n^{2-6}
Subtract 2 from 5.
\frac{\left(-4\right)^{1}}{6^{1}}m^{3}n^{-4}
Subtract 6 from 2.
-\frac{2}{3}m^{3}\times \frac{1}{n^{4}}
Reduce the fraction \frac{-4}{6} to lowest terms by extracting and canceling out 2.
\frac{\mathrm{d}}{\mathrm{d}m}(\left(-\frac{4n^{2}}{6n^{6}}\right)m^{5-2})
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{\mathrm{d}}{\mathrm{d}m}(\left(-\frac{2}{3n^{4}}\right)m^{3})
Do the arithmetic.
3\left(-\frac{2}{3n^{4}}\right)m^{3-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
\left(-\frac{2}{n^{4}}\right)m^{2}
Do the arithmetic.