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Differentiate w.r.t. x
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\left(x^{9}\right)^{-2}\times \frac{1}{x^{4}}
Use the rules of exponents to simplify the expression.
x^{9\left(-2\right)}x^{4\left(-1\right)}
To raise a power to another power, multiply the exponents.
x^{-18}x^{4\left(-1\right)}
Multiply 9 times -2.
x^{-18}x^{-4}
Multiply 4 times -1.
x^{-18-4}
To multiply powers of the same base, add their exponents.
x^{-22}
Add the exponents -18 and -4.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{x^{-18}}{x^{4}})
To raise a power to another power, multiply the exponents. Multiply 9 and -2 to get -18.
\frac{\mathrm{d}}{\mathrm{d}x}(\frac{1}{x^{22}})
Rewrite x^{4} as x^{-18}x^{22}. Cancel out x^{-18} in both numerator and denominator.
-\left(x^{22}\right)^{-1-1}\frac{\mathrm{d}}{\mathrm{d}x}(x^{22})
If F is the composition of two differentiable functions f\left(u\right) and u=g\left(x\right), that is, if F\left(x\right)=f\left(g\left(x\right)\right), then the derivative of F is the derivative of f with respect to u times the derivative of g with respect to x, that is, \frac{\mathrm{d}}{\mathrm{d}x}(F)\left(x\right)=\frac{\mathrm{d}}{\mathrm{d}x}(f)\left(g\left(x\right)\right)\frac{\mathrm{d}}{\mathrm{d}x}(g)\left(x\right).
-\left(x^{22}\right)^{-2}\times 22x^{22-1}
The derivative of a polynomial is the sum of the derivatives of its terms. The derivative of a constant term is 0. The derivative of ax^{n} is nax^{n-1}.
-22x^{21}\left(x^{22}\right)^{-2}
Simplify.