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\left(x^{2}-4\right)\left(x^{2}-25\right)=0
Variable x cannot be equal to any of the values -5,-2 since division by zero is not defined. Multiply both sides of the equation by \left(x+2\right)\left(x+5\right).
x^{4}-29x^{2}+100=0
Use the distributive property to multiply x^{2}-4 by x^{2}-25 and combine like terms.
t^{2}-29t+100=0
Substitute t for x^{2}.
t=\frac{-\left(-29\right)±\sqrt{\left(-29\right)^{2}-4\times 1\times 100}}{2}
All equations of the form ax^{2}+bx+c=0 can be solved using the quadratic formula: \frac{-b±\sqrt{b^{2}-4ac}}{2a}. Substitute 1 for a, -29 for b, and 100 for c in the quadratic formula.
t=\frac{29±21}{2}
Do the calculations.
t=25 t=4
Solve the equation t=\frac{29±21}{2} when ± is plus and when ± is minus.
x=5 x=-5 x=2 x=-2
Since x=t^{2}, the solutions are obtained by evaluating x=±\sqrt{t} for each t.
x=2 x=5
Variable x cannot be equal to any of the values -5,-2.