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Differentiate w.r.t. x
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\frac{\left(x^{\frac{4}{3}}y^{\frac{2}{3}}\right)^{\frac{1}{2}}\left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}}{x^{-4}\left(y^{\frac{1}{2}}\right)^{6}}
To raise a power to another power, multiply the exponents. Multiply \frac{1}{2} and -8 to get -4.
\frac{\left(x^{\frac{4}{3}}y^{\frac{2}{3}}\right)^{\frac{1}{2}}\left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
To raise a power to another power, multiply the exponents. Multiply \frac{1}{2} and 6 to get 3.
\frac{\left(x^{\frac{4}{3}}\right)^{\frac{1}{2}}\left(y^{\frac{2}{3}}\right)^{\frac{1}{2}}\left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
Expand \left(x^{\frac{4}{3}}y^{\frac{2}{3}}\right)^{\frac{1}{2}}.
\frac{x^{\frac{2}{3}}\left(y^{\frac{2}{3}}\right)^{\frac{1}{2}}\left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
To raise a power to another power, multiply the exponents. Multiply \frac{4}{3} and \frac{1}{2} to get \frac{2}{3}.
\frac{x^{\frac{2}{3}}y^{\frac{1}{3}}\left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
To raise a power to another power, multiply the exponents. Multiply \frac{2}{3} and \frac{1}{2} to get \frac{1}{3}.
\frac{x^{\frac{2}{3}}y^{\frac{1}{3}}\left(x^{\frac{2}{3}}\right)^{2}\left(y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
Expand \left(x^{\frac{2}{3}}y^{\frac{1}{3}}\right)^{2}.
\frac{x^{\frac{2}{3}}y^{\frac{1}{3}}x^{\frac{4}{3}}\left(y^{\frac{1}{3}}\right)^{2}}{x^{-4}y^{3}}
To raise a power to another power, multiply the exponents. Multiply \frac{2}{3} and 2 to get \frac{4}{3}.
\frac{x^{\frac{2}{3}}y^{\frac{1}{3}}x^{\frac{4}{3}}y^{\frac{2}{3}}}{x^{-4}y^{3}}
To raise a power to another power, multiply the exponents. Multiply \frac{1}{3} and 2 to get \frac{2}{3}.
\frac{x^{2}y^{\frac{1}{3}}y^{\frac{2}{3}}}{x^{-4}y^{3}}
To multiply powers of the same base, add their exponents. Add \frac{2}{3} and \frac{4}{3} to get 2.
\frac{x^{2}y^{1}}{x^{-4}y^{3}}
To multiply powers of the same base, add their exponents. Add \frac{1}{3} and \frac{2}{3} to get 1.
\frac{x^{2}}{x^{-4}y^{2}}
Cancel out y in both numerator and denominator.
\frac{x^{6}}{y^{2}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.