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Differentiate w.r.t. x
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\frac{4^{\frac{1}{2}}\left(x^{6}\right)^{\frac{1}{2}}\left(y^{2}\right)^{\frac{1}{2}}}{x^{-2}z^{-1}}
Expand \left(4x^{6}y^{2}\right)^{\frac{1}{2}}.
\frac{4^{\frac{1}{2}}x^{3}\left(y^{2}\right)^{\frac{1}{2}}}{x^{-2}z^{-1}}
To raise a power to another power, multiply the exponents. Multiply 6 and \frac{1}{2} to get 3.
\frac{4^{\frac{1}{2}}x^{3}y^{1}}{x^{-2}z^{-1}}
To raise a power to another power, multiply the exponents. Multiply 2 and \frac{1}{2} to get 1.
\frac{2x^{3}y^{1}}{x^{-2}z^{-1}}
Calculate 4 to the power of \frac{1}{2} and get 2.
\frac{2x^{3}y}{x^{-2}z^{-1}}
Calculate y to the power of 1 and get y.
\frac{2yx^{5}}{\frac{1}{z}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
2yx^{5}z
Divide 2yx^{5} by \frac{1}{z} by multiplying 2yx^{5} by the reciprocal of \frac{1}{z}.