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\frac{2^{3}\left(p^{-3}\right)^{3}\left(q^{6}\right)^{3}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(2p^{-3}q^{6}\right)^{3}.
\frac{2^{3}p^{-9}\left(q^{6}\right)^{3}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and 3 to get -9.
\frac{2^{3}p^{-9}q^{18}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 6 and 3 to get 18.
\frac{8p^{-9}q^{18}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Calculate 2 to the power of 3 and get 8.
\frac{8p^{-9}q^{18}\left(q^{-5}\right)^{-2}\left(r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(q^{-5}r^{6}\right)^{-2}.
\frac{8p^{-9}q^{18}q^{10}\left(r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -5 and -2 to get 10.
\frac{8p^{-9}q^{18}q^{10}r^{-12}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 6 and -2 to get -12.
\frac{8p^{-9}q^{28}r^{-12}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To multiply powers of the same base, add their exponents. Add 18 and 10 to get 28.
\frac{8p^{-9}q^{28}r^{-12}}{\left(p^{2}\right)^{-4}\left(q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(p^{2}q^{-3}\right)^{-4}.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}\left(q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 2 and -4 to get -8.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and -4 to get 12.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}\left(p^{-3}\right)^{2}\left(q^{5}\right)^{2}\left(r^{-2}\right)^{2}}
Expand \left(-3p^{-3}q^{5}r^{-2}\right)^{2}.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}\left(q^{5}\right)^{2}\left(r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and 2 to get -6.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}q^{10}\left(r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 5 and 2 to get 10.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}q^{10}r^{-4}}
To raise a power to another power, multiply the exponents. Multiply -2 and 2 to get -4.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\times 9p^{-6}q^{10}r^{-4}}
Calculate -3 to the power of 2 and get 9.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-14}q^{12}\times 9q^{10}r^{-4}}
To multiply powers of the same base, add their exponents. Add -8 and -6 to get -14.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-14}q^{22}\times 9r^{-4}}
To multiply powers of the same base, add their exponents. Add 12 and 10 to get 22.
\frac{8r^{-12}p^{-9}q^{6}}{9p^{-14}r^{-4}}
Cancel out q^{22} in both numerator and denominator.
\frac{8r^{-12}p^{5}q^{6}}{9r^{-4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{8p^{5}q^{6}}{9r^{8}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.
\frac{2^{3}\left(p^{-3}\right)^{3}\left(q^{6}\right)^{3}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(2p^{-3}q^{6}\right)^{3}.
\frac{2^{3}p^{-9}\left(q^{6}\right)^{3}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and 3 to get -9.
\frac{2^{3}p^{-9}q^{18}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 6 and 3 to get 18.
\frac{8p^{-9}q^{18}\left(q^{-5}r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Calculate 2 to the power of 3 and get 8.
\frac{8p^{-9}q^{18}\left(q^{-5}\right)^{-2}\left(r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(q^{-5}r^{6}\right)^{-2}.
\frac{8p^{-9}q^{18}q^{10}\left(r^{6}\right)^{-2}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -5 and -2 to get 10.
\frac{8p^{-9}q^{18}q^{10}r^{-12}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 6 and -2 to get -12.
\frac{8p^{-9}q^{28}r^{-12}}{\left(p^{2}q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To multiply powers of the same base, add their exponents. Add 18 and 10 to get 28.
\frac{8p^{-9}q^{28}r^{-12}}{\left(p^{2}\right)^{-4}\left(q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
Expand \left(p^{2}q^{-3}\right)^{-4}.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}\left(q^{-3}\right)^{-4}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 2 and -4 to get -8.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3p^{-3}q^{5}r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and -4 to get 12.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}\left(p^{-3}\right)^{2}\left(q^{5}\right)^{2}\left(r^{-2}\right)^{2}}
Expand \left(-3p^{-3}q^{5}r^{-2}\right)^{2}.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}\left(q^{5}\right)^{2}\left(r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply -3 and 2 to get -6.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}q^{10}\left(r^{-2}\right)^{2}}
To raise a power to another power, multiply the exponents. Multiply 5 and 2 to get 10.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\left(-3\right)^{2}p^{-6}q^{10}r^{-4}}
To raise a power to another power, multiply the exponents. Multiply -2 and 2 to get -4.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-8}q^{12}\times 9p^{-6}q^{10}r^{-4}}
Calculate -3 to the power of 2 and get 9.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-14}q^{12}\times 9q^{10}r^{-4}}
To multiply powers of the same base, add their exponents. Add -8 and -6 to get -14.
\frac{8p^{-9}q^{28}r^{-12}}{p^{-14}q^{22}\times 9r^{-4}}
To multiply powers of the same base, add their exponents. Add 12 and 10 to get 22.
\frac{8r^{-12}p^{-9}q^{6}}{9p^{-14}r^{-4}}
Cancel out q^{22} in both numerator and denominator.
\frac{8r^{-12}p^{5}q^{6}}{9r^{-4}}
To divide powers of the same base, subtract the denominator's exponent from the numerator's exponent.
\frac{8p^{5}q^{6}}{9r^{8}}
To divide powers of the same base, subtract the numerator's exponent from the denominator's exponent.